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KMID : 0882420050680030299
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Korean Journal of Medicine
2005 Volume.68 No. 3 p.299 ~ p.307
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Prognostic significance of age in curatively resected gastric cancer
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Song Hong-Seok
Do Young-Rok
Ryu Seung-Wan
Kim In-Ho
Sohn Soo-Sang
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Abstract
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Background: The purpose of this study was to clarify whether the patients’ age is an independent prognostic factor in curatively resected gastric adenocarcinoma.
Methods: Clinicopathologic information was reviewed for consecutive patients undergoing curative gastrectomy for gastric cancer during 6-year period (Jan. 1996-Dec. 2001) at the Keimyung University School of Medicine at Daegu. Overall survival was examined by the Kaplan-Meier method, and multivariate analysis by Cox proportional hazards was used to identify whether age had independent prognostic significance for survival.
Results: The patients were divided into two groups: 838 patients (72.4%) with age of less than 65 years old, and 320 patients (27.6%) with age more than 65 years old. In these two groups, there were statistically differences in WHO classification, Lauren classification, vascular invasion, T stage, total stage, operational morbidity and mortality, and overall survival rate. The 5-year overall survival rate of age less than 65 years old was 87.8%, and 83.0% of age more than 65 years old (p=0.019). Multivariate Cox regression analysis revealed that age was an independent prognostic factor to predict overall survival in curatively resected gastric cancer (p=0.038). However, after excluding cases who died within 1 month after gastric resection, overall survival rate was significantly different between two groups (p=0.050), but Cox regression analysis showed that age was not an independent prognostic factor (p=0.054).
Conclusion: The age is not an independent prognostic factor in curatively resected gastric cancer patients, and survival differences are due to an increased operative mortality in elderly patients.
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KEYWORD
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Gastric cancer, Prognosis, Age
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